The southeast U.S. is widely perceived as a water rich region, yet recent droughts, highly variable streamflows, and rapidly growing demands for water have revealed vulnerabilities and the potential for widespread water scarcity. In this research, we identify patterns and trends in regional streamflow records in AL, GA, MS, and the Gulf of Mexico region of northwest FL and investigate potential causes of observed patterns and trends (climatic variability, land use change, and other factors). Further, we aim to perform a regional vulnerability assessment focused on water availability for thermoelectric power production.